Fused Ridge Regression on High-Dimensional (Wide) Data5 months ago
Introduction | The Problem: Data Leakage in Two-Stage Models | Realistic Synthetic Experiment | 1. Data Generation | 2. Nested Cross-Validation (The "No Leakage" Approach) | Results and Visualization | 1. Predictive Performance (AUC) | 2. Coefficient Trajectories | Anatomically-Grounded Example: Predicting Cognitive Decline | 1. Data Preparation with Anatomical Context | 2. The Power of Sparse Selection | 3. Evaluating Actual Predictions | 4. Visualizing Anatomical Patterns | Real-World Application: Blood-Brain Barrier (BBB) Permeability | 1. Data Preparation | 2. Identifying Stable Molecular Signatures | 4. Visualizing the Molecular Signature | Conclusion